Mechanochemical-hydrothermal synthesis of hydroxyapatite from nonionic surfactant emulsion precursors

Chun Wei Chen, Richard E. Riman, Kevor S. TenHuisen, Kelly Brown

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31 Scopus citations


Nanocrystalline hydroxyapatite [HA, Ca10(PO4) 6(OH)2] powders were synthesized by the mechanochemical-hydrothermal method using emulsion systems consisting of aqueous phase, petroleum ether (PE) as the oil phase and biodegradable Tomadol 23-6.5 as the nonionic surfactant. (NH4)4HPO4 and Ca(NO3)2 or Ca(OH)2 were used as the phosphorus and calcium sources, respectively. The calcium source and emulsion composition had significant effects on the stoichiometry, crystallinity, thermal stability, particle size and morphology of final products. Disperse HA crystals with a 160nm length and aspect ratio of ca. 6 were formed in an emulsion system containing 10wt% PE, 60wt% water and 30wt% surfactant. The HA particles had needle morphology with a specific surface area of 190m2/g. With this technique, HA nanopowders with specific surface areas in the range of 72-231 m2/g were produced.

Original languageEnglish (US)
Pages (from-to)615-623
Number of pages9
JournalJournal of Crystal Growth
Issue number3-4
StatePublished - Oct 1 2004

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Materials Chemistry


  • A1. Biomaterials
  • A1. Characterization
  • A1. Mechanochemical
  • A2. Hydrothermal
  • B1. Hydroxyapatite


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