Mechanochemical Synthesis of Ketones via Chemoselective Suzuki-Miyaura Cross-Coupling of Acyl Chlorides

Jin Zhang, Pei Zhang, Yangmin Ma, Michal Szostak

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The direct synthesis of ketones via acyl Suzuki-Miyaura cross-coupling of widely available acyl chlorides is a central transformation in organic synthesis. Herein, we report the first mechanochemical solvent-free method for highly chemoselective synthesis of ketones from acyl chlorides and boronic acids. This acylation reaction is conducted in the solid state, in the absence of potentially harmful solvents, for a short reaction time and shows excellent selectivity for C(acyl)-Cl bond cleavage.

Original languageEnglish (US)
Pages (from-to)2338-2343
Number of pages6
JournalOrganic letters
Volume24
Issue number12
DOIs
StatePublished - Apr 1 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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