TY - JOUR
T1 - Membrane-associated DNA transport machines.
AU - Burton, Briana
AU - Dubnau, David
PY - 2010/7/1
Y1 - 2010/7/1
N2 - DNA pumps play important roles in bacteria during cell division and during the transfer of genetic material by conjugation and transformation. The FtsK/SpoIIIE proteins carry out the translocation of double-stranded DNA to ensure complete chromosome segregation during cell division. In contrast, the complex molecular machines that mediate conjugation and genetic transformation drive the transport of single stranded DNA. The transformation machine also processes this internalized DNA and mediates its recombination with the resident chromosome during and after uptake, whereas the conjugation apparatus processes DNA before transfer. This article reviews these three types of DNA pumps, with attention to what is understood of their molecular mechanisms, their energetics and their cellular localizations.
AB - DNA pumps play important roles in bacteria during cell division and during the transfer of genetic material by conjugation and transformation. The FtsK/SpoIIIE proteins carry out the translocation of double-stranded DNA to ensure complete chromosome segregation during cell division. In contrast, the complex molecular machines that mediate conjugation and genetic transformation drive the transport of single stranded DNA. The transformation machine also processes this internalized DNA and mediates its recombination with the resident chromosome during and after uptake, whereas the conjugation apparatus processes DNA before transfer. This article reviews these three types of DNA pumps, with attention to what is understood of their molecular mechanisms, their energetics and their cellular localizations.
UR - http://www.scopus.com/inward/record.url?scp=77958182576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958182576&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a000406
DO - 10.1101/cshperspect.a000406
M3 - Review article
C2 - 20573715
AN - SCOPUS:77958182576
SN - 1943-0264
VL - 2
SP - a000406
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 7
ER -