Membrane properties for permeability testing: Skin versus synthetic membranes

Anika Haq, Mania Dorrani, Benjamin Goodyear, Vivek Joshi, Bozena Michniak-Kohn

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Synthetic membranes that are utilized in diffusion studies for topical and transdermal formulations are usually porous thin polymeric sheets for example cellulose acetate (CA) and polysulfones. In this study, the permeability of human skin was compared using two synthetic membranes: cellulose acetate and Strat-M® membrane and lipophilic and hydrophilic compounds either as saturated or formulated solutions as well as marketed dosage forms. Our data suggests that hydrophilic compounds have higher permeation in Strat-M membranes compared with lipophilic ones. High variation in permeability values, a typical property of biological membranes, was not observed with Strat-M. In addition, the permeability of Strat-M was closer to that of human skin than that of cellulose acetate (CA > Strat-M > Human skin). Our results suggest that Strat-M with little or no lot to lot variability can be applied in pilot studies of diffusion tests instead of human skin and is a better substitute than a cellulose acetate.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume539
Issue number1-2
DOIs
StatePublished - Mar 25 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Cellulose acetate membrane
  • Diffusion study
  • Skin permeation
  • Strat-M membrane

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