Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Zoe Cournia, Toby W. Allen, Ioan Andricioaei, Bruno Antonny, Daniel Baum, Grace Brannigan, Nicolae Viorel Buchete, Jason T. Deckman, Lucie Delemotte, Coral del Val, Ran Friedman, Paraskevi Gkeka, Hans Christian Hege, Jérôme Hénin, Marina A. Kasimova, Antonios Kolocouris, Michael L. Klein, Syma Khalid, M. Joanne Lemieux, Norbert LindowMahua Roy, Jana Selent, Mounir Tarek, Florentina Tofoleanu, Stefano Vanni, Sinisa Urban, David J. Wales, Jeremy C. Smith, Ana Nicoleta Bondar

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

Original languageEnglish (US)
Pages (from-to)611-640
Number of pages30
JournalJournal of Membrane Biology
Volume248
Issue number4
DOIs
StatePublished - Aug 27 2015

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Physiology
  • Cell Biology

Keywords

  • Lipids
  • Membrane proteins
  • Membrane-mediated interactions
  • Protein dynamics
  • Protein function
  • Protein structure

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