Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

Robert M. Anthony, Joseph F. Urban, Farhang Alem, Hossein A. Hamed, Cristina T. Rozo, Jean Luc Boucher, Nico Van Rooijen, William C. Gause

Research output: Contribution to journalArticlepeer-review

394 Scopus citations

Abstract

Although primary and memory responses against bacteria and viruses have been studied extensively, T helper type 2 (TH2) effector mechanisms leading to host protection against helminthic parasites remain elusive. Examination of the intestinal epithelial submucosa of mice after primary and secondary infections by a natural gastrointestinal parasite revealed a distinct immune-cell infiltrate after challenge, featuring interleukin-4-expressing memory CD4+ T cells that induced IL-4 receptorhi (IL-4Rhi) CD206+ alternatively activated macrophages. In turn, these alternatively activated macrophages (AAMacs) functioned as important effector cells of the protective memory response contributing to parasite elimination, demonstrating a previously unknown mechanism for host protection against intestinal helminths.

Original languageEnglish (US)
Pages (from-to)955-960
Number of pages6
JournalNature medicine
Volume12
Issue number8
DOIs
StatePublished - Aug 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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