Mesenchymal stem cells: A new trend for cell therapy

Xin Wei, Xue Yang, Zhi Peng Han, Fang Fang Qu, Li Shao, Yu Fang Shi

Research output: Contribution to journalReview articlepeer-review

641 Scopus citations

Abstract

Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical applications, and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic.

Original languageEnglish (US)
Pages (from-to)747-754
Number of pages8
JournalActa Pharmacologica Sinica
Volume34
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Keywords

  • cell therapy
  • degenerative disease
  • graft-versus-host disease
  • immune disorder
  • immunomodulation
  • mesenchymal stem cell
  • tissue injury
  • trophic factor

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