Mesenchymal stem cells as therapeutics

Biju Parekkadan, Jack M. Milwid

Research output: Contribution to journalReview articlepeer-review

468 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afforded by MSC transplantation are short-lived and related to dynamic, paracrine interactions between MSCs and host cells. Therefore, representations of MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology, therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics.

Original languageEnglish (US)
Pages (from-to)87-117
Number of pages31
JournalAnnual Review of Biomedical Engineering
Volume12
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

Keywords

  • clinical trials
  • conditioned medium
  • extracorporeal bioreactor
  • immunotherapy
  • mesenchymal stem cell
  • paracrine

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