Mesenchymal stromal cell variables influencing clinical potency: the impact of viability, fitness, route of administration and host predisposition

Jacques Galipeau, Mauro Krampera, Katarina Leblanc, Jan A. Nolta, Donald G. Phinney, Yufang Shi, Karin Tarte, Sowmya Viswanathan, Ivan Martin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The International Society for Cell & Gene Therapy mesenchymal stromal cell (MSC) committee has been an interested observer of community interests in all matters related to MSC identity, mechanism of action, potency assessment and etymology, and it has regularly contributed to this conversation through a series of MSC pre-conferences and committee publications dealing with these matters. Arising from these reflections, the authors propose that an overlooked and potentially disruptive perspective is the impact of in vivo persistence on potency that is not predicted by surrogate cellular potency assays performed in vitro and how this translates to in vivo outcomes. Systemic delivery or extravascular implantation at sites removed from the affected organ system seems to be adequate in affecting clinical outcomes in many pre-clinical murine models of acute tissue injury and inflammatory pathology, including the recent European Medicines Agency-approved use of MSCs in Crohn-related fistular disease. The authors further propose that MSC viability and metabolic fitness likely dominate as a potency quality attribute, especially in recipients poised for salutary benefits as defined by emerging predictive biomarkers of response.

Original languageEnglish (US)
Pages (from-to)368-372
Number of pages5
JournalCytotherapy
Volume23
Issue number5
DOIs
StatePublished - May 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Transplantation
  • Cancer Research

Keywords

  • ISCT MSC committee
  • biomarkers
  • clinical use
  • efferocytosis
  • mesenchymal stromal cells
  • potency
  • viability

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