Meta-analysis of loci associated with age at natural menopause in African-American women

Christina T.L. Chen, Ching Ti Liu, Gary K. Chen, Jeanette S. Andrews, Alice M. Arnold, Jill Dreyfus, Nora Franceschini, Melissa E. Garcia, Kathleen F. Kerr, Guo Li, Kurt K. Lohman, Solomon K. Musani, Michael A. Nalls, Leslie J. Raffel, Jennifer Smith, Christine B. Ambrosone, Elisa V. Bandera, Leslie Bernstein, Angela Britton, Robert G. BrzyskiAnne Cappola, Christopher S. Carlson, David Couper, Sandra L. Deming, Mark O. Goodarzi, Gerardo Heiss, Esther M. John, Xiaoning Lu, Loic Le Marchand, Kristin Marciante, Barbara Mcknight, Robert Millikan, Nora L. Nock, Andrew F. Olshan, Michael F. Press, Dhananjay Vaiyda, Nancy F. Woods, Herman A. Taylor, Wei Zhao, Wei Zheng, Michele K. Evans, Tamara B. Harris, Brian E. Henderson, Sharon L.R. Kardia, Charles Kooperberg, Yongmei Liu, Thomas H. Mosley, Bruce Psaty, Melissa Wellons, Beverly G. Windham, Alan B. Zonderman, L. Adrienne Cupples, Ellen W. Demerath, Christopher Haiman, Joanne M. Murabito, Aleksandar Rajkovic

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Age atmenopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders.GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at men opause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with Africanancestry derivedfrom 11studies across the USA.We did not identify any additional loci significantly associated with age at men opause in African Americans.We replicated the associations between six lociandage at men opause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Original languageEnglish (US)
Pages (from-to)3327-3342
Number of pages16
JournalHuman molecular genetics
Volume23
Issue number12
DOIs
StatePublished - Jun 15 2014

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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