Metabolic control of virulence factor production in Staphylococcus aureus

Paulami Rudra, Jeffrey M. Boyd

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

As investigators decipher the underlining mechanisms of Staphylococcus aureus pathogenesis, it is becoming apparent that perturbations in central metabolism alter virulence factor production and infection outcomes. It is also evident that S. aureus has the ability to metabolically adapt to improve colonization and overcome challenges imparted by the immune system. Altered metabolite pools modify virulence factor production suggesting that proper functioning of a core metabolic network is necessary for successful niche colonization and pathogenesis. Herein we discuss four examples of transcriptional regulators that monitor metabolic status. These regulatory systems sense perturbations in the metabolic network and respond by altering the transcription of genes utilized for central metabolism, energy generation and pathogenesis.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalCurrent Opinion in Microbiology
Volume55
DOIs
StatePublished - Jun 2020

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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