Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico

Heng Xie, Lifang Hou, Peter G. Shields, Deborah M. Winn, Gloria Gridley, Eleuterio Bravo-Otero, Scott Diehl, Elise D. Bowman, Linda M. Brown, Richard B. Hayes

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Genetic polymorphisms resulting in variation in metabolism of tobacco carcinogens may influence oral cancer risk. In a population-based case-control study in Puerto Rico, genotypes of CYP1A1, GSTM1, and GSTT1 were determined by a PCR-based method for 132 oral cancer patients and 143 control subjects. Genotype-associated risks were estimated by logistic regression. The null variant of GSTM1 was associated with a marginally significant decrease in oral cancer risk [odds ratio (OR) = 0.6, 95% confidence interval (CI) = 0.3-1.0, and P for trend = 0.09]. Risks increased with increasing cigarette use among subjects with the GSTM1-present genotype (P for trend <0.0001), rising to OR = 9.5, 95% CI = 3.0-30, among the heaviest cigarette users. In contrast, among subjects with the GSTM1-null genotype, risks did not clearly increase with increasing cigarette use (P for trend <0.61; OR= 1.8, 95% CI = 0.6-5.2 among the heaviest tobacco users). The GSTT1-null variant (OR = 1.0, 95% CI = 0.5-1.9) and CYP1A1462Val variant (OR= 0.9, 95% CI = 0.5-1.7) were not associated with the risk. Risks rose with increasing cigarette use in a similar manner for subjects with or without the CYP1A1462Val variant (P for interaction = 0.3) and for subjects with or without the GSTT1-null genotype (P for interaction = 0.4). In conclusion, cigarette use significantly increased the risk of oral cancer in this population. The GSTM1-present genotype was associated with higher tobacco-associated risk for oral cancer among heavy smokers than the null genotype.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalOncology Research
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2003

Fingerprint

Puerto Rico
Mouth Neoplasms
Smoking
Genotype
Tobacco Products
Odds Ratio
Confidence Intervals
Tobacco
Cytochrome P-450 CYP1A1
Genetic Polymorphisms
Carcinogens
Population
Case-Control Studies
Logistic Models
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Carcinoma
  • Enzymes
  • Polymorphism
  • Smoking

Cite this

Xie, H., Hou, L., Shields, P. G., Winn, D. M., Gridley, G., Bravo-Otero, E., ... Hayes, R. B. (2003). Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico. Oncology Research, 14(6), 315-320. https://doi.org/10.3727/096504003773994851
Xie, Heng ; Hou, Lifang ; Shields, Peter G. ; Winn, Deborah M. ; Gridley, Gloria ; Bravo-Otero, Eleuterio ; Diehl, Scott ; Bowman, Elise D. ; Brown, Linda M. ; Hayes, Richard B. / Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico. In: Oncology Research. 2003 ; Vol. 14, No. 6. pp. 315-320.
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Xie, H, Hou, L, Shields, PG, Winn, DM, Gridley, G, Bravo-Otero, E, Diehl, S, Bowman, ED, Brown, LM & Hayes, RB 2003, 'Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico', Oncology Research, vol. 14, no. 6, pp. 315-320. https://doi.org/10.3727/096504003773994851

Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico. / Xie, Heng; Hou, Lifang; Shields, Peter G.; Winn, Deborah M.; Gridley, Gloria; Bravo-Otero, Eleuterio; Diehl, Scott; Bowman, Elise D.; Brown, Linda M.; Hayes, Richard B.

In: Oncology Research, Vol. 14, No. 6, 01.01.2003, p. 315-320.

Research output: Contribution to journalArticle

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T1 - Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico

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AU - Hayes, Richard B.

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AB - Genetic polymorphisms resulting in variation in metabolism of tobacco carcinogens may influence oral cancer risk. In a population-based case-control study in Puerto Rico, genotypes of CYP1A1, GSTM1, and GSTT1 were determined by a PCR-based method for 132 oral cancer patients and 143 control subjects. Genotype-associated risks were estimated by logistic regression. The null variant of GSTM1 was associated with a marginally significant decrease in oral cancer risk [odds ratio (OR) = 0.6, 95% confidence interval (CI) = 0.3-1.0, and P for trend = 0.09]. Risks increased with increasing cigarette use among subjects with the GSTM1-present genotype (P for trend <0.0001), rising to OR = 9.5, 95% CI = 3.0-30, among the heaviest cigarette users. In contrast, among subjects with the GSTM1-null genotype, risks did not clearly increase with increasing cigarette use (P for trend <0.61; OR= 1.8, 95% CI = 0.6-5.2 among the heaviest tobacco users). The GSTT1-null variant (OR = 1.0, 95% CI = 0.5-1.9) and CYP1A1462Val variant (OR= 0.9, 95% CI = 0.5-1.7) were not associated with the risk. Risks rose with increasing cigarette use in a similar manner for subjects with or without the CYP1A1462Val variant (P for interaction = 0.3) and for subjects with or without the GSTT1-null genotype (P for interaction = 0.4). In conclusion, cigarette use significantly increased the risk of oral cancer in this population. The GSTM1-present genotype was associated with higher tobacco-associated risk for oral cancer among heavy smokers than the null genotype.

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Xie H, Hou L, Shields PG, Winn DM, Gridley G, Bravo-Otero E et al. Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico. Oncology Research. 2003 Jan 1;14(6):315-320. https://doi.org/10.3727/096504003773994851