Metacaspases

L. Tsiatsiani, F. Van Breusegem, P. Gallois, A. Zavialov, E. Lam, P. V. Bozhkov

Research output: Contribution to journalReview articlepeer-review

209 Scopus citations

Abstract

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of the metacaspase function and molecular regulation during programmed cell death, stress and cell proliferation, as well as an analysis of the first metacaspase-mediated proteolytic pathway. To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases.

Original languageEnglish (US)
Pages (from-to)1279-1288
Number of pages10
JournalCell Death and Differentiation
Volume18
Issue number8
DOIs
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • caspase
  • cell proliferation
  • in vivo degradome
  • metacaspase
  • protein aggregation
  • substrate specificity

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