Metal exposures in an inner-city neonatal population

Elizabeth A. Jones, J. Michael Wright, Glenn Rice, Brian T. Buckley, Melina S. Magsumbol, Dana B. Barr, Bryan L. Williams

    Research output: Contribution to journalArticlepeer-review

    52 Scopus citations

    Abstract

    Objectives: We measured concentrations of lead (Pb), manganese (Mn), chromium (Cr), and copper (Cu) in umbilical cord whole blood and examined sources of environmental Pb exposures in a predominantly African-American population. Methods: Between April and July 2006, we collected reproductive histories, questionnaires, and blood samples from 102 women, aged 16-45. years, who delivered at a Memphis, TN hospital. Results: The prevalence of preeclampsia and low birth weight infancy in the study population was 11% and 10%, respectively. Twenty-eight percent of mothers reported living near a potential Pb-contaminated area, while 43% lived in a residence built before 1978. Geometric mean (GM) concentrations for umbilical cord blood in the study population were 1.3, 3.5, 9.0, and 52.0μg/dL for Pb, Mn, Cr, and Cu, respectively. Six neonates had cord blood Pb (CBL) concentrations above 10μg/dL, while 20 had CBL concentrations ≥ 2μg/dL. GM umbilical CBL levels were higher in neonates born to women living near a potential Pb-contaminated area (2.2 vs. 1.1μg/dL) and those with friends, family or household members exposed to lead products (1.6 vs. 1.1μg/dL). Some evidence of an exposure-response relationship was also detected between all four metal concentrations and an increasing number of maternal lead exposures. After adjustment for confounding, proximity to a Pb-contaminated area was the strongest environmental determinant of CBL levels among neonates with CBL concentrations of ≥ 2μg/dL (odds ratio. =5.1; 95% CI. =1.6, 16.7). Conclusions: Metal concentrations were elevated in this population, and CBL levels were associated with proximity to Pb-contaminated areas.

    Original languageEnglish (US)
    Pages (from-to)649-654
    Number of pages6
    JournalEnvironment international
    Volume36
    Issue number7
    DOIs
    StatePublished - Oct 2010

    All Science Journal Classification (ASJC) codes

    • Environmental Science(all)

    Keywords

    • Environmental epidemiology
    • Lead
    • Metals
    • Pregnancy
    • Urban health

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