Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice

Taizo Kita; Keiji Shimada; Yasunori Mastunari; George C. Wagner; Kaoru Kubo; Toshikatsu Nakashima

doi:10.1016/S0028-3908(99)00175-6

Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice

Taizo Kita, Keiji Shimada, Yasunori Mastunari, George C. Wagner, Kaoru Kubo, Toshikatsu Nakashima

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kgx4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	399-406
Number of pages	8
Journal	Neuropharmacology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/S0028-3908(99)00175-6
State	Published - Mar 2000

All Science Journal Classification (ASJC) codes

Pharmacology
Cellular and Molecular Neuroscience

Keywords

Cyclooxygenase-2
Dopamine depletion
Hyperthermia
Methamphetamine
Striatum

Access to Document

10.1016/S0028-3908(99)00175-6

Cite this

@article{651f34d09ed34810976b0a51a60d62da,

title = "Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice",

abstract = "The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kgx4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum. Copyright (C) 2000 Elsevier Science Ltd.",

keywords = "Cyclooxygenase-2, Dopamine depletion, Hyperthermia, Methamphetamine, Striatum",

author = "Taizo Kita and Keiji Shimada and Yasunori Mastunari and Wagner, {George C.} and Kaoru Kubo and Toshikatsu Nakashima",

year = "2000",

month = mar,

doi = "10.1016/S0028-3908(99)00175-6",

language = "English (US)",

volume = "39",

pages = "399--406",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice

AU - Kita, Taizo

AU - Shimada, Keiji

AU - Mastunari, Yasunori

AU - Wagner, George C.

AU - Kubo, Kaoru

AU - Nakashima, Toshikatsu

PY - 2000/3

Y1 - 2000/3

N2 - The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kgx4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum. Copyright (C) 2000 Elsevier Science Ltd.

AB - The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kgx4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum. Copyright (C) 2000 Elsevier Science Ltd.

KW - Cyclooxygenase-2

KW - Dopamine depletion

KW - Hyperthermia

KW - Methamphetamine

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0033977231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033977231&partnerID=8YFLogxK

U2 - 10.1016/S0028-3908(99)00175-6

DO - 10.1016/S0028-3908(99)00175-6

M3 - Article

C2 - 10698006

AN - SCOPUS:0033977231

SN - 0028-3908

VL - 39

SP - 399

EP - 406

JO - Neuropharmacology

JF - Neuropharmacology

IS - 3

ER -

Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this