Methotrexate Therapy of Head and Neck Cancer: Improvement in Therapeutic Index by the Use of Leucovorin “Rescue”

R. L. Capizzi, Joseph Bertino

Research output: Contribution to journalArticle

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Twenty-one patients with advanced epidermoid carcinoma of the head and neck were treated with 24-hr infusions of methotrexate followed by leucovorin rescue repeated at 4-day intervals. Thirteen of the 21 patients responded with a greater than 50% reduction of tumor mass and 7 of the 13 sustained a greater than 75% reduction. The median duration of tumor regression was 16 weeks. In general, toxicity was tolerable. The rationale of this regimen and its comparison with other methotrexate schedules is discussed.

Original languageEnglish (US)
Pages (from-to)1782-1788
Number of pages7
JournalCancer Research
Issue number6
StatePublished - Jan 1 1970


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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