MgZnO Dual Gate Thin Film Transistor for the Sensitive Determination of Modified Folic Acid

Guangyuan Li, Yuan Chen, Fangzhou Yu, Jonathan Viereck, Pavel I. Reyes, Richard Mendelsohn, Elena Galoppini, Yicheng Lu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Folate receptor (FR) is a typical tumor-associated antigen that has been widely used as a biomarker for the determination of cancer. A biosensing platform functionalized with folic acid (FA) is essential to FR detection because FA specifically binds FR. We demonstrate an MgZnO dual-gate thin-film transistor (MZO DGTFT) based biosensor for the sensitive determination of FA derivative, hexadecyl alkynated folic acid (HAFA). The receptor is an MZO nanostructure (MZO nano) modified sensing pad which electrically connects to the top gate of DGTFT. The bottom gate of DGTFT is used to bias the device to its optimum operation point, enabling high sensitivity. First, 11-azidoundecanoic acid (AA) was bond onto the MZO nano surface as the linker layer, resulting in negative charges to MZO nano due to carboxylic acid binding chemistry. HAFA was then immobilized on MZO nano via click reaction with AA. HAFA is a polar molecule with the positive end adjacent to AA/MZO nano, and therefore, the electrostatic condition of MZO nano is impacted again. Such changes were detected by DGTFT that displayed significant drain current variations. Fourier-transform infrared spectroscopy (FTIR) imaging confirms such successful chemical processes. This MZO DGTFT biosensor with HAFA is promising for potential applications in the detection of FR overexpressed cancer cells.

Original languageEnglish (US)
Article number9294088
Pages (from-to)7242-7249
Number of pages8
JournalIEEE Sensors Journal
Volume21
Issue number6
DOIs
StatePublished - Mar 15 2021

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Electrical and Electronic Engineering

Keywords

  • Click chemistry
  • dual-gate thin film transistor
  • hexadecyl alkynated folic acid
  • magnesium zinc oxide
  • nanostructures

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