MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity

Jacqueline G. Perrigoue, Steven A. Saenz, Mark C. Siracusa, Eric J. Allenspach, Betsy C. Taylor, Paul R. Giacomin, Meera G. Nair, Yurong Du, Colby Zaph, Nico van Rooijen, Michael R. Comeau, Edward J. Pearce, Terri M. Laufer, David Artis

Research output: Contribution to journalArticlepeer-review

478 Scopus citations

Abstract

Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II-dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.

Original languageEnglish (US)
Pages (from-to)697-705
Number of pages9
JournalNature Immunology
Volume10
Issue number7
DOIs
StatePublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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