Mice lacking L1 have reduced CGRP fibre in-growth into spinal transection lesions

Ronald Deumens, Miriam Lübbers, Robby J.P. Jaken, Matthijs F.L. Meijs, Rogier M. Thurlings, Wiel M.M. Honig, Melitta Camartin, Gary A. Brook, Elbert A.J. Joosten

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Repair strategies for spinal cord injury often focus on promoting regeneration of injured axons and stimulating subsequent functional recovery. Although many of these strategies have proven their merits, less is known about potential unwanted side-effects, such as sprouting of nociceptive CGRP immunoreactive axons, which may bring about pain-related behavior. Sprouting of CGRP axons into lesion sites spontaneously occurs after spinal cord injury (SCI). Using L1-deficient mice we show a reduction of such CGRP growth response. This reduction was specific for CGRP axons since the overall neurofilament positive fibre in-growth into the spinal lesion site was not affected. Our results may have important implications on the development and assessment of repair strategies that should not only stimulate functional recovery, but also prevent the development of pain or autonomic dysreflexia.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalNeuroscience Letters
Volume420
Issue number3
DOIs
StatePublished - Jun 15 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Central sensitization
  • Mechanisms
  • Pain
  • Spinal cord injury
  • Sprouting

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    Deumens, R., Lübbers, M., Jaken, R. J. P., Meijs, M. F. L., Thurlings, R. M., Honig, W. M. M., Camartin, M., Brook, G. A., & Joosten, E. A. J. (2007). Mice lacking L1 have reduced CGRP fibre in-growth into spinal transection lesions. Neuroscience Letters, 420(3), 277-281. https://doi.org/10.1016/j.neulet.2007.05.015