Microarray-based resequencing of multiple Bacillus anthracis isolates.

Michael E. Zwick, Farrell Mcafee, David J. Cutler, Timothy D. Read, Jacques Ravel, Gregory R. Bowman, Darrell R. Galloway, Alfred Mateczun

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

We used custom-designed resequencing arrays to generate 3.1 Mb of genomic sequence from a panel of 56 Bacillus anthracis strains. Sequence quality was shown to be very high by replication (discrepancy rate of 7.4 x 10(-7)) and by comparison to independently generated shotgun sequence (discrepancy rate < 2.5 x 10(-6)). Population genomics studies of microbial pathogens using rapid resequencing technologies such as resequencing arrays are critical for recognizing newly emerging or genetically engineered strains.

Original languageEnglish (US)
Pages (from-to)R10
JournalGenome biology
Volume6
Issue number1
StatePublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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