Microbial transformation of widely used pharmaceutical and personal care product compounds

Abigail W. Porter; Sarah J. Wolfson; Max Häggblom; Lily Y. Youn

doi:10.12688/f1000research.21827.1

Microbial transformation of widely used pharmaceutical and personal care product compounds

Abigail W. Porter, Sarah J. Wolfson, Max Häggblom, Lily Y. Youn

School of Environmental and Biological Sciences, Biochemistry & Microbiology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

Original language	English (US)
Article number	130
Journal	F1000Research
Volume	9
DOIs	https://doi.org/10.12688/f1000research.21827.1
State	Published - 2020

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Keywords

Anaerobic O-demethylation
Anaerobic o-methylation
Biotransformation
Pharmaceutical biodegradation

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10.12688/f1000research.21827.1

Cite this

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title = "Microbial transformation of widely used pharmaceutical and personal care product compounds",

abstract = "Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.",

keywords = "Anaerobic O-demethylation, Anaerobic o-methylation, Biotransformation, Pharmaceutical biodegradation",

author = "Porter, {Abigail W.} and Wolfson, {Sarah J.} and Max H{\"a}ggblom and Youn, {Lily Y.}",

note = "Funding Information: Grant information: This work was supported by the USDA National Institute of Food and Agriculture Hatch Multistate project 1007899 through the New Jersey Agricultural Experiment Station Hatch Multistate NJ07212 and Hatch project NJ01160. S.J.W. was supported by a U.S. National Science Foundation Fuels IGERT (NSF DGE 0903675) from Rutgers, the State University of New Jersey. Publisher Copyright: {\textcopyright} 2020 Porter AW et al.",

year = "2020",

doi = "10.12688/f1000research.21827.1",

language = "English (US)",

volume = "9",

journal = "F1000Research",

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T1 - Microbial transformation of widely used pharmaceutical and personal care product compounds

AU - Porter, Abigail W.

AU - Wolfson, Sarah J.

AU - Häggblom, Max

AU - Youn, Lily Y.

N1 - Funding Information: Grant information: This work was supported by the USDA National Institute of Food and Agriculture Hatch Multistate project 1007899 through the New Jersey Agricultural Experiment Station Hatch Multistate NJ07212 and Hatch project NJ01160. S.J.W. was supported by a U.S. National Science Foundation Fuels IGERT (NSF DGE 0903675) from Rutgers, the State University of New Jersey. Publisher Copyright: © 2020 Porter AW et al.

PY - 2020

Y1 - 2020

N2 - Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

AB - Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

KW - Anaerobic O-demethylation

KW - Anaerobic o-methylation

KW - Biotransformation

KW - Pharmaceutical biodegradation

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VL - 9

JO - F1000Research

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ER -

Microbial transformation of widely used pharmaceutical and personal care product compounds

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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