Microchannel bioreactors for bioartificial liver support

Jaesung Park, Mehmet Toner, Martin L. Yarmush, Arno W. Tilles

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An extracorporeal bioartificial liver (BAL) device containing viable hepatocytes has the potential to provide temporary hepatic support to liver failure patients, serving as a bridge to transplantation while awaiting a suitable donor. In some patients, providing temporary hepatic support may be sufficient to allow adequate regeneration of the host liver, thereby eliminating the need for a liver transplant. Although the BAL device is a promising technology for the treatment of liver failure, there are several technical challenges that must be overcome in order to develop systems with sufficient processing capacity and of manageable size. In this study, the authors describe the critical issues involved in developing a BAL device. They also discuss their experiences in hepatocyte culture optimization within the context of a microchannel flat-plate BAL device.

Original languageEnglish (US)
Pages (from-to)525-535
Number of pages11
JournalMicrofluidics and Nanofluidics
Volume2
Issue number6
DOIs
StatePublished - Nov 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

Keywords

  • Bioreactor
  • Hepatocyte
  • Microgrooves
  • Oxygen
  • Shear stress

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