Microdialysis microneedles for continuous medical monitoring

Jeffrey D. Zahn, David Trebotich, Dorian Liepmann

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Enzyme based biosensors suffer from loss of activity and sensitivity through a variety of processes. One major reason for the loss is through large molecular weight proteins settling onto the sensor and affecting sensor signal stability and disrupting enzyme function. One way to minimize loss of sensor activity is to filter out large molecular weight compounds before sensing small biochemicals such as glucose. A novel microdialysis microneedle is introduced that is capable of excluding large MW compounds based on size. Preliminary experimental evidence of membrane permeability is shown, as well as diffusion and permeability modeling. Microdialysis microneedles present an attractive first step towards decreasing size, patient discomfort and energy consumption of portable medical monitors over existing technologies.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalBiomedical Microdevices
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology

Keywords

  • Microdialysis
  • Microneedle
  • Microshell
  • Porous polysilicon

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