Microemulsion-based media in nose-to-brain drug delivery

Anna Froelich, Tomasz Osmałek, Barbara Jadach, Vinam Puri, Bozena Michniak-Kohn

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered intranasally can be delivered directly to the central nervous system. The most important advantage of this approach is the ability to avoid the blood–brain barrier surrounding the brain and blocking the entry of exogenous substances to the central nervous system. Moreover, selective brain targeting could possibly avoid peripheral side effects of pharmacotherapy. The challenges associated with nose-to-brain drug delivery are mostly due to the small volume of the nasal cavity and insufficient drug absorption from nasal mucosa. These issues could be minimized by using a properly designed drug carrier. Microemulsions as potential drug delivery systems offer good solubilizing properties and the ability to enhance drug permeation through biological membranes. The aim of this review is to summarize the current status of the research focused on microemulsion-based systems for nose-to-brain delivery with special attention to the most extensively investigated neurological and psychiatric conditions, such as neurodegenerative diseases, epilepsy, and schizophrenia.

Original languageEnglish (US)
Article number201
Pages (from-to)1-37
Number of pages37
JournalPharmaceutics
Volume13
Issue number2
DOIs
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Blood–brain barrier
  • Drug delivery
  • Microemulsion
  • Nose to brain

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