Microenvironmental influence on breast cancer dormancy and metastasis

George R. Nahas, Jacqueline M. Park, Pranela Rameshwar

Research output: Chapter in Book/Report/Conference proceedingChapter


Breast cancer remains a serious public health issue; this despite early diagnosis and aggressive treatment. This chapter discusses the different aspects that are contributors in the evasion of cancer. The review discusses the emerging role of cancer stem cells in dormancy. Included in the discussion are studies on mesenchymal stem cells as protection for the cancer cells from immune clearance. We reviewed the role of hormones and the intracellular pathways in metastasis. Overall, this review provides a 'snapshot' of breast cancer subset in dormancy and immune evasion.

Original languageEnglish (US)
Title of host publicationTumor Dormancy, Quiescence, and Senescence
Subtitle of host publicationAging, Cancer, and Noncancer Pathologies
PublisherSpringer Netherlands
Number of pages11
ISBN (Electronic)9789400759589
ISBN (Print)9789400759572
StatePublished - Jan 1 2013


All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Bone marrow
  • Breast cancer
  • Dormancy
  • Metastasis
  • Stem cell

Cite this

Nahas, G. R., Park, J. M., & Rameshwar, P. (2013). Microenvironmental influence on breast cancer dormancy and metastasis. In Tumor Dormancy, Quiescence, and Senescence: Aging, Cancer, and Noncancer Pathologies (Vol. 1, pp. 23-33). Springer Netherlands. https://doi.org/10.1007/978-94-007-5958-9_3