Microfluidic toxicological platform for the monitoring of extracellular ionic activities

Silvia Generelli, Francois Berthiaume, Martin L. Yarmush, Mario Jolicoeur, Milena Koudelka-Hep, Olivier T. Guenat

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A microfluidic toxicological platform aimed at the real-time monitoring of ionic cellular responses is being developed. These responses are assessed with ion-selective microelectrodes integrated in the platform. First cellular assays were successfully performed by monitoring the increasing K+ concentration generated by induced cell necrosis.

Original languageEnglish (US)
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages164-166
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Externally publishedYes
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: Oct 7 2007Oct 11 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period10/7/0710/11/07

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Keywords

  • Cell necrosis
  • Ion-selective microelectrodes
  • Toxicological platform

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