Microglial phagocytosis of dopamine neurons at early phases of apoptosis

Byung Pil Cho, Shuei Sugama, Dong Hoon Shin, Lorraine A. DeGiorgio, Sung Soo Kim, Yoon Seong Kim, So Young Lim, Key Chung Park, Bruce T. Volpe, Sunghee Cho, Tong H. Joh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and OX-6 (MHC-II marker)-positive and ED1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. The occurrence of microglial phagocytosis at early stages of apoptosis may indicate the evolution of apoptosis into an irreversible state. Alternatively, interventions that suppress early activation of microglia might lead to novel mechanisms for neuron protection.

Original languageEnglish (US)
Pages (from-to)551-560
Number of pages10
JournalCellular and Molecular Neurobiology
Volume23
Issue number4-5
DOIs
StatePublished - Oct 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Keywords

  • Apoptosis
  • Axotomy
  • Dopamine neurons
  • Microglia
  • Phagocytosis

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