Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat

Vineet C. Chitravanshi; Hreday N. Sapru

doi:10.1016/j.brainres.2005.06.023

Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat

Vineet C. Chitravanshi, Hreday N. Sapru

NJMS-Neurosurgery

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 ± 4, 33.3 ± 2.9, 16.5 ± 1.5 and 13.9 ± 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Brain research
Volume	1051
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.06.023
State	Published - Jul 27 2005

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Glutamate
Heart rate
ORL1 receptor

Access to Document

10.1016/j.brainres.2005.06.023

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title = "Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat",

abstract = "Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 ± 4, 33.3 ± 2.9, 16.5 ± 1.5 and 13.9 ± 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.",

keywords = "Glutamate, Heart rate, ORL1 receptor",

author = "Chitravanshi, {Vineet C.} and Sapru, {Hreday N.}",

note = "Funding Information: This work was supported by N.I.H. grants HL24347 and HL076248 awarded to Dr. H. N. Sapru.",

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AU - Chitravanshi, Vineet C.

AU - Sapru, Hreday N.

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AB - Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 ± 4, 33.3 ± 2.9, 16.5 ± 1.5 and 13.9 ± 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.

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