Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat

Vineet C. Chitravanshi, Hreday N. Sapru

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 ± 4, 33.3 ± 2.9, 16.5 ± 1.5 and 13.9 ± 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalBrain research
Volume1051
Issue number1-2
DOIs
StatePublished - Jul 27 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Glutamate
  • Heart rate
  • ORL1 receptor

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