Microneedle insertion force reduction using vibratory actuation

Ming Yang, Jeffrey D. Zahn

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to insert microneedles into excized animal tissue was measured with a load cell. Results showed a greater than 70% reduction in microneedle insertion force by using vibratory actuation. The application of vibratory actuation provides a promising method to precisely control the microneedle insertion forces to overcome microneedle structural material limitations, minimize insertion pain, and enhance the efficiency of drug delivery.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalBiomedical Microdevices
Volume6
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology

Keywords

  • Drug delivery
  • Insertion force
  • Microneedle
  • Vibratory actuation

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