MicroRNA function in NK-cell biology

Aimee M. Beaulieu; Natalie A. Bezman; Jang Eun Lee; Mehrdad Matloubian; Joseph C. Sun; Lewis L. Lanier

doi:10.1111/imr.12045

MicroRNA function in NK-cell biology

Aimee M. Beaulieu, Natalie A. Bezman, Jang Eun Lee, Mehrdad Matloubian, Joseph C. Sun, Lewis L. Lanier

New Jersey Medical School (NJMS), Center for Immunity and Inflammation (CII)

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.

Original language	English (US)
Pages (from-to)	40-52
Number of pages	13
Journal	Immunological Reviews
Volume	253
Issue number	1
DOIs	https://doi.org/10.1111/imr.12045
State	Published - May 2013

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

Keywords

Cytotoxicity
Development
MicroRNA
NK
Natural killer

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10.1111/imr.12045

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abstract = "The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.",

keywords = "Cytotoxicity, Development, MicroRNA, NK, Natural killer",

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AU - Lanier, Lewis L.

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AB - The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.

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MicroRNA function in NK-cell biology

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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