MicroRNAs in neurodegenerative disorders

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs regulating eukaryotic gene expression at the post-transcriptional level. During the last decade, considerable advances have been made in our understanding the biogenesis of miRNAs, the molecular mechanisms by which they regulate gene expression and their functional role in various physiological situations. miRNAs are abundant in the brain where they have crucial roles in development and synaptic plasticity. Accumulating evidence from postmortem brain analyses and animal model studies has begun to suggest that miRNA dysfunction contributes to neurodegenerative disorders. Here, we discuss several examples of investigations demonstrating the role of miRNAs in neurodegenerative disorders. As the expression of disease-causing genes is regulated by certain miRNA(s), changes in these miRNAs could lead to the accumulation of disease-causing proteins, and subsequently to neuronal dysfunction and death. Detailed understanding of these mechanisms can provide potential new therapeutic approaches to slow down or halt the progression of neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)1717-1721
Number of pages5
JournalCell Cycle
Volume9
Issue number9
DOIs
StatePublished - May 1 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

  • Alzheimer's disease
  • Dicer
  • Neurodegenerative disorder
  • Parkinson's disease
  • SNP
  • miRNA

Fingerprint Dive into the research topics of 'MicroRNAs in neurodegenerative disorders'. Together they form a unique fingerprint.

Cite this