MicroRNAs: Small regulators with a big impact

Maocheng Yang; Ying Li; Richard W. Padgett

doi:10.1016/j.cytogfr.2005.02.008

MicroRNAs: Small regulators with a big impact

Maocheng Yang, Ying Li, Richard W. Padgett

Waksman Institute of Microbiology

Research output: Contribution to journal › Short survey › peer-review

58 Scopus citations

Abstract

MicroRNAs (miRNA) are non-coding small (∼22 nt) RNAs that regulate diverse physiological and developmental processes. In animals, they regulate target genes by binding imperfectly to 3′UTR sequences in mRNAs and attenuate translation. There are hundreds of miRNA genes in animals, and current studies show they constitute a minimum of 1% of known genes. We are just beginning to understand the diverse roles they play in cellular processes, which include signaling pathways, developmental pathways, and possibly various types of cancers.

Original language	English (US)
Pages (from-to)	387-393
Number of pages	7
Journal	Cytokine and Growth Factor Reviews
Volume	16
Issue number	4-5
DOIs	https://doi.org/10.1016/j.cytogfr.2005.02.008
State	Published - Aug 2005

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

Keywords

Development
Gene regulation
MicroRNA
RNA

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10.1016/j.cytogfr.2005.02.008

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title = "MicroRNAs: Small regulators with a big impact",

abstract = "MicroRNAs (miRNA) are non-coding small (∼22 nt) RNAs that regulate diverse physiological and developmental processes. In animals, they regulate target genes by binding imperfectly to 3′UTR sequences in mRNAs and attenuate translation. There are hundreds of miRNA genes in animals, and current studies show they constitute a minimum of 1% of known genes. We are just beginning to understand the diverse roles they play in cellular processes, which include signaling pathways, developmental pathways, and possibly various types of cancers.",

keywords = "Development, Gene regulation, MicroRNA, RNA",

author = "Maocheng Yang and Ying Li and Padgett, {Richard W.}",

note = "Funding Information: Work on miRNAs in our lab is supported by an Academic Excellence Grant from Rutgers University, and funds from the Cancer Institute of New Jersey. Y. Li is supported by a Busch Predoctoral Fellow.",

year = "2005",

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doi = "10.1016/j.cytogfr.2005.02.008",

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pages = "387--393",

journal = "Cytokine and Growth Factor Reviews",

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T1 - MicroRNAs

T2 - Small regulators with a big impact

AU - Yang, Maocheng

AU - Li, Ying

AU - Padgett, Richard W.

N1 - Funding Information: Work on miRNAs in our lab is supported by an Academic Excellence Grant from Rutgers University, and funds from the Cancer Institute of New Jersey. Y. Li is supported by a Busch Predoctoral Fellow.

PY - 2005/8

Y1 - 2005/8

N2 - MicroRNAs (miRNA) are non-coding small (∼22 nt) RNAs that regulate diverse physiological and developmental processes. In animals, they regulate target genes by binding imperfectly to 3′UTR sequences in mRNAs and attenuate translation. There are hundreds of miRNA genes in animals, and current studies show they constitute a minimum of 1% of known genes. We are just beginning to understand the diverse roles they play in cellular processes, which include signaling pathways, developmental pathways, and possibly various types of cancers.

AB - MicroRNAs (miRNA) are non-coding small (∼22 nt) RNAs that regulate diverse physiological and developmental processes. In animals, they regulate target genes by binding imperfectly to 3′UTR sequences in mRNAs and attenuate translation. There are hundreds of miRNA genes in animals, and current studies show they constitute a minimum of 1% of known genes. We are just beginning to understand the diverse roles they play in cellular processes, which include signaling pathways, developmental pathways, and possibly various types of cancers.

KW - Development

KW - Gene regulation

KW - MicroRNA

KW - RNA

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DO - 10.1016/j.cytogfr.2005.02.008

M3 - Short survey

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AN - SCOPUS:22644440849

SN - 1359-6101

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EP - 393

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 4-5

ER -

MicroRNAs: Small regulators with a big impact

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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