Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients

Luis Ulloa, Esteban Montejo de Garcini, Pilar Gómez-Ramos, María A. Morán, Jesús Avila

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites. It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures. Here, we show that another microtubule associated protein, MAP1B, aberrantly phosphorylated by a proline-dependent protein kinase, is a component of these previously mentioned structures. Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalMolecular Brain Research
Volume26
Issue number1-2
DOIs
StatePublished - Oct 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Keywords

  • Cytoskeletal disorder
  • Proline-dependent phosphorylation

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