Microvascular pathophysiology of skeletal muscle ischemia-reperfusion

W. N. Duran, H. Takenaka, R. W. Hobson

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Ischemia-reperfusion injury is a continuing challenge to vascular surgeons. Microvascular factors and mechanisms underlying edema and compartment syndrome provide a useful end point for analysis and planning of therapy. We review the pivotal role of endothelium-leukocyte interactions and of cytokines in the genesis of postischemic damage in muscle. Clinical considerations and future directions based on research and practice are presented.

Original languageEnglish (US)
Pages (from-to)203-214
Number of pages12
JournalSeminars in Vascular Surgery
Issue number3
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine


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