Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility

Nadine K. Gut; Juan Mena-Segovia

doi:10.1016/j.tins.2022.04.005

Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility

Nadine K. Gut, Juan Mena-Segovia

Rutgers Newark, Center for Molecular and Behavioral Neuroscience

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.

Original language	English (US)
Pages (from-to)	502-503
Number of pages	2
Journal	Trends in Neurosciences
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.tins.2022.04.005
State	Published - Jul 2022

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

acetylcholine
pedunculopontine
reversal learning

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10.1016/j.tins.2022.04.005

Cite this

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title = "Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility",

abstract = "Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.",

keywords = "acetylcholine, pedunculopontine, reversal learning",

author = "Gut, {Nadine K.} and Juan Mena-Segovia",

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year = "2022",

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AU - Gut, Nadine K.

AU - Mena-Segovia, Juan

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N2 - Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.

AB - Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.

KW - acetylcholine

KW - pedunculopontine

KW - reversal learning

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DO - 10.1016/j.tins.2022.04.005

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AN - SCOPUS:85129710886

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JO - Trends in Neurosciences

JF - Trends in Neurosciences

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ER -

Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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