Mini-mouse: Disruption of the pygmy locus in a transgenic insertional mutant

Xin Xiang, Kathleen F. Benson, Kiran Chada

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


A founder transgenic mouse harbored two different integration patterns ofa transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were alielic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development.

Original languageEnglish (US)
Pages (from-to)967-969
Number of pages3
Issue number4945
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • General


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