Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer

J. Dongun Kim; Douglas H. Pike; Alexei M. Tyryshkin; G. V.T. Swapna; Hagai Raanan; Gaetano T. Montelione; Vikas Nanda; Paul G. Falkowski

doi:10.1021/jacs.8b07553

Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer

J. Dongun Kim, Douglas H. Pike, Alexei M. Tyryshkin, G. V.T. Swapna, Hagai Raanan, Gaetano T. Montelione, Vikas Nanda, Paul G. Falkowski

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Ambidoxin is a designed, minimal dodecapeptide consisting of alternating L and D amino acids that binds a 4Fe-4S cluster through ligand-metal interactions and an extensive network of second-shell hydrogen bonds. The peptide can withstand hundreds of oxidation-reduction cycles at room temperature. Ambidoxin suggests how simple, prebiotic peptides may have achieved robust redox catalysis on the early Earth.

Original language	English (US)
Pages (from-to)	11210-11213
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	140
Issue number	36
DOIs	https://doi.org/10.1021/jacs.8b07553
State	Published - Sep 12 2018

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/jacs.8b07553

Cite this

@article{198b7217765e494eb9f359ca39d19a5c,

title = "Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer",

abstract = "Ambidoxin is a designed, minimal dodecapeptide consisting of alternating L and D amino acids that binds a 4Fe-4S cluster through ligand-metal interactions and an extensive network of second-shell hydrogen bonds. The peptide can withstand hundreds of oxidation-reduction cycles at room temperature. Ambidoxin suggests how simple, prebiotic peptides may have achieved robust redox catalysis on the early Earth.",

author = "Kim, {J. Dongun} and Pike, {Douglas H.} and Tyryshkin, {Alexei M.} and Swapna, {G. V.T.} and Hagai Raanan and Montelione, {Gaetano T.} and Vikas Nanda and Falkowski, {Paul G.}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = sep,

day = "12",

doi = "10.1021/jacs.8b07553",

language = "English (US)",

volume = "140",

pages = "11210--11213",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "36",

}

TY - JOUR

T1 - Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer

AU - Kim, J. Dongun

AU - Pike, Douglas H.

AU - Tyryshkin, Alexei M.

AU - Swapna, G. V.T.

AU - Raanan, Hagai

AU - Montelione, Gaetano T.

AU - Nanda, Vikas

AU - Falkowski, Paul G.

PY - 2018/9/12

Y1 - 2018/9/12

N2 - Ambidoxin is a designed, minimal dodecapeptide consisting of alternating L and D amino acids that binds a 4Fe-4S cluster through ligand-metal interactions and an extensive network of second-shell hydrogen bonds. The peptide can withstand hundreds of oxidation-reduction cycles at room temperature. Ambidoxin suggests how simple, prebiotic peptides may have achieved robust redox catalysis on the early Earth.

AB - Ambidoxin is a designed, minimal dodecapeptide consisting of alternating L and D amino acids that binds a 4Fe-4S cluster through ligand-metal interactions and an extensive network of second-shell hydrogen bonds. The peptide can withstand hundreds of oxidation-reduction cycles at room temperature. Ambidoxin suggests how simple, prebiotic peptides may have achieved robust redox catalysis on the early Earth.

UR - http://www.scopus.com/inward/record.url?scp=85053001127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053001127&partnerID=8YFLogxK

U2 - 10.1021/jacs.8b07553

DO - 10.1021/jacs.8b07553

M3 - Article

C2 - 30141918

AN - SCOPUS:85053001127

SN - 0002-7863

VL - 140

SP - 11210

EP - 11213

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Minimal Heterochiral de Novo Designed 4Fe-4S Binding Peptide Capable of Robust Electron Transfer

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this