TY - JOUR
T1 - Mitochondrial and plastid evolution in eukaryotes
T2 - An outsiders' perspective
AU - Gross, Jeferson
AU - Bhattacharya, Debashish
N1 - Funding Information:
We acknowledge the comments from various colleagues, especially M.-A. Bailey, D. Callahan, L. Friedman Ross, J. John, R. Leidl and J. Schmidtke. All errors of omission and commission remain our own. W.R. was partly supported by EuroGentest, an EU-FP6 supported NoE contract number 512148 (EuroGentest Unit 3: Clinical genetics, community genetics and public health, Workpackage 3.2 (J. Schmidtke)). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention.
Funding Information:
D.B. acknowledges support from the National Science Foundation and the National Institutes of Health. The authors also thank W. Lanier (Iowa) for a critical reading of the manuscript.
PY - 2009/7
Y1 - 2009/7
N2 - The eukaryotic organelles mitochondrion and plastid originated from eubacterial endosymbionts. Here we propose that, in both cases, prokaryote-to-organelle conversion was driven by the internalization of host-encoded factors progressing from the outer membrane of the endosymbionts towards the intermembrane space, inner membrane and finally the organelle interior. This was made possible by an outside-to-inside establishment in the endosymbionts of host-controlled protein-sorting components, which enabled the gradual integration of organelle functions into the nuclear genome. Such a convergent trajectory for mitochondrion and plastid establishment suggests a novel paradigm for organelle evolution that affects theories of eukaryogenesis.
AB - The eukaryotic organelles mitochondrion and plastid originated from eubacterial endosymbionts. Here we propose that, in both cases, prokaryote-to-organelle conversion was driven by the internalization of host-encoded factors progressing from the outer membrane of the endosymbionts towards the intermembrane space, inner membrane and finally the organelle interior. This was made possible by an outside-to-inside establishment in the endosymbionts of host-controlled protein-sorting components, which enabled the gradual integration of organelle functions into the nuclear genome. Such a convergent trajectory for mitochondrion and plastid establishment suggests a novel paradigm for organelle evolution that affects theories of eukaryogenesis.
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U2 - 10.1038/nrg2610
DO - 10.1038/nrg2610
M3 - Review article
C2 - 19506574
AN - SCOPUS:67649755680
SN - 1471-0056
VL - 10
SP - 495
EP - 505
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 7
ER -