TY - JOUR
T1 - Mitophagy as a protective mechanism against myocardial stress
AU - Nah, Jihoon
AU - Miyamoto, Shigeki
AU - Sadoshima, Junichi
N1 - Funding Information:
The authors thank Daniela Zablocki for critical reading of the manuscript. This work was supported in part by American Heart Association 15GRNT2297009 (S. Miyamoto), U.S. Public Health Service Grants R56HL097037 (S. Miyamoto), HL67724, HL91469, HL102738, HL112330, and AG23039 (J. Sadoshima), and by the Leducq Foundation Transatlantic Networks of Excellence (J. Sadoshima)
Publisher Copyright:
© 2017 American Physiological Society.
PY - 2017/10
Y1 - 2017/10
N2 - Mitochondria are dynamic organelles that can undergo fusion, fission, biogenesis, and autophagic elimination to maintain mitochondrial quality control. Since the heart is in constant need of high amounts of energy, mitochondria, as a central energy supply source, play a crucial role in maintaining optimal cardiac performance. Therefore, it is reasonable to assume that mitochondrial dysfunction is associated with the pathophysiology of heart diseases. In non-dividing, post-mitotic cells such as cardiomyocytes, elimination of dysfunctional organelles is essential to maintaining cellular function because non-dividing cells cannot dilute dysfunctional organelles through cell division. In this review, we discuss the recent findings regarding the physiological role of mitophagy in the heart and cardiomyocytes. Moreover, we discuss the functional role of mitophagy in the progression of cardiovascular diseases, including myocardial ischemic injury, diabetic cardiomyopathy, cardiac hypertrophy, and heart failure.
AB - Mitochondria are dynamic organelles that can undergo fusion, fission, biogenesis, and autophagic elimination to maintain mitochondrial quality control. Since the heart is in constant need of high amounts of energy, mitochondria, as a central energy supply source, play a crucial role in maintaining optimal cardiac performance. Therefore, it is reasonable to assume that mitochondrial dysfunction is associated with the pathophysiology of heart diseases. In non-dividing, post-mitotic cells such as cardiomyocytes, elimination of dysfunctional organelles is essential to maintaining cellular function because non-dividing cells cannot dilute dysfunctional organelles through cell division. In this review, we discuss the recent findings regarding the physiological role of mitophagy in the heart and cardiomyocytes. Moreover, we discuss the functional role of mitophagy in the progression of cardiovascular diseases, including myocardial ischemic injury, diabetic cardiomyopathy, cardiac hypertrophy, and heart failure.
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U2 - 10.1002/cphy.c170005
DO - 10.1002/cphy.c170005
M3 - Article
C2 - 28915329
AN - SCOPUS:85045329946
SN - 2040-4603
VL - 7
SP - 1407
EP - 1424
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 4
ER -