Abstract
A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.
Original language | English (US) |
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Article number | R178 |
Journal | Genome biology |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Cell Biology