Model building using bi-level optimization

G. K.D. Saharidis, I. P. Androulakis, M. G. Ierapetritou

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In many problems from different disciplines such as engineering, physics, medicine, and biology, a series of experimental data is used in order to generate a model that can describe a system with minimum noise. The procedure for building a model provides a description of the behavior of the system under study and can be used to give a prediction for the future. Herein a novel hierarchical bi-level implementation of the cross validation method is presented. In this bi-level schema, the leader optimization problem builds (training) the model and the follower checks (testing) the developed model. The problem of synthesis and analysis of regulatory networks is used to compare the classical cross validation method to the proposed methodology referred to as bi-level cross validation. In all the examples considered, the bi-level cross validation results in a better model compared with the classical cross validation approach.

Original languageEnglish (US)
Pages (from-to)49-67
Number of pages19
JournalJournal of Global Optimization
Issue number1
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Control and Optimization
  • Applied Mathematics
  • Business, Management and Accounting (miscellaneous)
  • Computer Science Applications
  • Management Science and Operations Research


  • Bi-level optimization
  • Cross-validation
  • Model building
  • Regulatory networks


Dive into the research topics of 'Model building using bi-level optimization'. Together they form a unique fingerprint.

Cite this