Modeling and Optimization of Continuous Pharmaceutical Manufacturing Processes

Amanda Rogers, Marianthi Ierapetritou

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


The increased availability of software tools for solids-based process modeling has created opportunities to enhance pharmaceutical development through the use of models. In particular, recent work in the area of integrated process modeling has demonstrated the potential of these simulations to complement experimental studies during process development. Once developed, these models also facilitate the use of other mathematical tools like process feasibility analysis and optimization. This work will emphasize recent developments in the area of flowsheet modeling for pharmaceutical processes. Methods for feasibility analysis and optimization of these complex process models will also be discussed. These tools can play an important role in pharmaceutical process development.

Original languageEnglish (US)
Title of host publicationComputer Aided Chemical Engineering
PublisherElsevier B.V.
Number of pages8
StatePublished - Jan 1 2015

Publication series

NameComputer Aided Chemical Engineering
ISSN (Print)1570-7946

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications


  • Feasibility analysis
  • Flowsheet modelling
  • Surrogate-based optimization

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