Modeling DNA supercoils and knots with B‐spline functions

Ming‐Hong ‐H Hao, Wilma K. Olson

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


A method is offered to model the complex trajectories of closed circular DNA supercoils and knots. The trajectories are approximated by polygons and analytical expressions of the curves are generated from the polygons with B‐spline functions. The resulting curves are used to evaluate the writhe and elastic energy of a series of interrelated supercoils, and to generate detailed atomic models of the deformed double helix.

Original languageEnglish (US)
Pages (from-to)873-900
Number of pages28
Issue number4
StatePublished - Apr 1989

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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