Modeling of multi-component granule formation in a wet granulation process

Frantisek Stepanek, Rohit Ramachandran, Pavol Rajniak, Rey Chern, Chris Mancinelli

Research output: Contribution to conferencePaperpeer-review

Abstract

A methodology for in silico formation of realistic three-dimensional virtual granules consisting of multiple types of primary particles and a liquid binder has been developed. Populations of virtual granules with varying composition and binder content have been generated for the case of smooth, rough, hydrophilic and hydrophobic primary particles and their combinations. The equilibrium distribution of liquid binder within the wet granule microstructure was found in each case by the volume-of-fluid (VOF) method and the fraction of surface binder accessible during granule-particle collision was determined by a particle shooting method. The functional dependence of the accessible binder fraction on the volumetric composition of granules was thereby constructed and its sensitivity on the primary particle properties (shape and wettability) established. This functional dependence is an important input for a multi-variate population balance model of low-shear wet granulation.

Original languageEnglish (US)
StatePublished - 2006
Externally publishedYes
Event2006 AIChE Spring National Meeting - 5th World Congress on Particle Technology - Orlando, FL, United States
Duration: Apr 23 2006Apr 27 2006

Other

Other2006 AIChE Spring National Meeting - 5th World Congress on Particle Technology
Country/TerritoryUnited States
CityOrlando, FL
Period4/23/064/27/06

All Science Journal Classification (ASJC) codes

  • General Chemical Engineering
  • General Chemistry

Keywords

  • Computer simulation
  • Granulation
  • Microstructure
  • Morphology
  • Wetting

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