Abstract
An electromechanical model, combining stretch-activated ion channels and mechanical function of mesangial cell membrane, was formulated to approach and analyze hypotonically-induced swelling in isolated kidney mesangial cells. Simulation results showed that the osmotic gradient was rapidly nullfied by solute efflux and water dilution within 15 seconds, followed by a negative overshooting that gradually returned to the baseline. It is suggested that the reversed osmotic gradient may be partially responsible for volume shrinkage after initial swelling in mesangial cells.
| Original language | English (US) |
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| Pages | 111-112 |
| Number of pages | 2 |
| State | Published - 1996 |
| Event | Proceedings of the IEEE 22nd Annual Northeast Bioengineering Conference - New Brunswick, NJ, USA Duration: Mar 14 1996 → Mar 15 1996 |
Other
| Other | Proceedings of the IEEE 22nd Annual Northeast Bioengineering Conference |
|---|---|
| City | New Brunswick, NJ, USA |
| Period | 3/14/96 → 3/15/96 |
All Science Journal Classification (ASJC) codes
- Bioengineering