Modeling the dentate gyrus

Robert J. Morgan, Vijayalakshmi Santhakumar, Ivan Soltesz

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Scopus citations

Abstract

Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process, akin to putting together a jigsaw puzzle with the pieces being such things as cell types, cell numbers, and specific connectivity. This chapter provides a walkthrough for the development of a very large-scale, biophysically realistic model of the dentate gyrus. Subsequently, it demonstrates the utility of a modeling approach in asking and answering questions about both healthy and pathological states involving the modeled brain region. Finally, this chapter discusses some predictions that come directly from the model that can be tested in future experimental approaches.

Original languageEnglish (US)
Title of host publicationThe Dentate Gyrus
Subtitle of host publicationA Comprehensive Guide to Structure, Function, and Clinical Implications
EditorsHelen Scharfman
Pages639-658
Number of pages20
DOIs
StatePublished - 2007
Externally publishedYes

Publication series

NameProgress in Brain Research
Volume163
ISSN (Print)0079-6123

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • computational model
  • epilepsy
  • granule cell
  • interneuron
  • mossy cell
  • sclerosis

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