Modification of Christensen urease test as an inexpensive tool for detection of Helicobacter pylori

María G. Domínguez-Bello, Fabián Michelangeli, Roberto Romero, Bernardo Beker, Domingo Lara, Claudio Morera, María A. Vezga, Vicenzo Spardella, Moisés Guelrud, María E. Pérez, Luis R. Pericchi

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


About half the world population is infected with Helicobacter pylori. Most live in developing countries where clinical studies face the constraints of high costs of improved rapid diagnostic tests. In this work, we describe and validate a simple local urease test (LUT) to determine the presence of the bacterium in gastric biopsies, and report the incidence of infection among symptomatic patients in Caracas, Venezuela. Statistical comparison of LUT and CLOtest (Delta West, Bentley, Australia) (N = 216 patients) showed that the probability of 95% agreement between the two was 0.936. Overall incidence of infection determined by the LUT was 65% (N = 229), and it was higher in patients from public (72%; N = 153) than from private (50%; N = 76) hospitals (p = .001). Therefore, the incidence of infection differs in two socioeconomic groups that coexist in the same city. LUT may represent an affordable tool in clinical studies needed to identify social factors that increase the risk of infection by H. pylori.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Issue number3
StatePublished - Jul 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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