Modified ecarin clotting time test monitors the anticoagulant effects of hirudin

Arpita Gandhi, David Kristol, Charles Spillert

Research output: Contribution to conferencePaperpeer-review

Abstract

A rapid blood clotting test for monitoring the thrombin inhibiting activity of the drug hirudin is described. This test, a modified ecarin clotting time, may enable the monitoring of a patient's hirudin dosage so that a safe, therapeutic level is achieved. The results show that there was an increase in clotting time with an increased level of hirudin. The data demonstrates a linear correlation between ecarin clotting time prolongation and hirudin content. Each clotting time is significantly prolonged (p<0.01) in comparison to the clotting time at lower concentrations.

Original languageEnglish (US)
Pages100-101
Number of pages2
StatePublished - Jan 1 1999
Externally publishedYes
EventProceedings of the 1999 IEEE/EMBS 25th Annual Northeast Bioengineering Conference - West Hartford, CT, USA
Duration: Apr 8 1999Apr 9 1999

Other

OtherProceedings of the 1999 IEEE/EMBS 25th Annual Northeast Bioengineering Conference
CityWest Hartford, CT, USA
Period4/8/994/9/99

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

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