Abstract
A rapid blood clotting test for monitoring the thrombin inhibiting activity of the drug hirudin is described. This test, a modified ecarin clotting time, may enable the monitoring of a patient's hirudin dosage so that a safe, therapeutic level is achieved. The results show that there was an increase in clotting time with an increased level of hirudin. The data demonstrates a linear correlation between ecarin clotting time prolongation and hirudin content. Each clotting time is significantly prolonged (p<0.01) in comparison to the clotting time at lower concentrations.
| Original language | English (US) |
|---|---|
| Pages | 100-101 |
| Number of pages | 2 |
| State | Published - Jan 1 1999 |
| Externally published | Yes |
| Event | Proceedings of the 1999 IEEE/EMBS 25th Annual Northeast Bioengineering Conference - West Hartford, CT, USA Duration: Apr 8 1999 → Apr 9 1999 |
Other
| Other | Proceedings of the 1999 IEEE/EMBS 25th Annual Northeast Bioengineering Conference |
|---|---|
| City | West Hartford, CT, USA |
| Period | 4/8/99 → 4/9/99 |
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)