Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures

Deepak Nagrath, Vanessa Lopez, Francois Berthiaume, Martin Yarmush

Research output: Contribution to conferencePaper

Abstract

Nuclear Hormone Receptors are ligand activated transcription factors which are activated by binding to lipophilic ligands. The activated nuclear transcription factors have emerged as important regulators of lipid and glucose metabolism. These activated receptors, although pleitropic in nature, have been found to regulate the expression of genes involved in lipid and glucose metabolism and homeostasis. The modulation of these receptors provides a suitable therapeutic strategy for the management of various diseases ranging from diabetes to obesity. The current work investigates three different invitro hepatocyte cultures (lean hepatocytes; fatty-hepatocytes made fatty invitro using a high fat diet and;choline methionine deficient diet induced steatosis hepatocytes). Using various ligands for these receptors we have developed strategies for regulating lipid and glucose metabolism and, increasing hepatic functions in cultured hepatocytes for bioartificial liver. Importantly, our results suggest a new mechanism to differentially regulate/promote fatty oxidation and limit lipid esterification and storage in hepatocytes using various agonists and antagonists of these nuclear receptors.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 2005
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

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Lipids
Glucose
Metabolism
Transcription factors
Ligands
Nutrition
Esterification
Medical problems
Oils and fats
Liver
Cytoplasmic and Nuclear Receptors
Hepatocytes
Genes
Modulation
Oxidation

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Nagrath, D., Lopez, V., Berthiaume, F., & Yarmush, M. (2005). Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures. Paper presented at 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States.
Nagrath, Deepak ; Lopez, Vanessa ; Berthiaume, Francois ; Yarmush, Martin. / Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures. Paper presented at 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States.1 p.
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Nagrath, D, Lopez, V, Berthiaume, F & Yarmush, M 2005, 'Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures', Paper presented at 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05 - 11/4/05.

Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures. / Nagrath, Deepak; Lopez, Vanessa; Berthiaume, Francois; Yarmush, Martin.

2005. Paper presented at 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States.

Research output: Contribution to conferencePaper

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Nagrath D, Lopez V, Berthiaume F, Yarmush M. Modulating nuclear receptors to regulate lipid and glucose homeostasis for hepatic functions in lean and fatty hepatocytes cultures. 2005. Paper presented at 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States.