Modulating stiffness in DNA-crosslinked polyacrylamide gels

David C. Lin, Noshir A. Langrana, Bernard Yurke

Research output: Contribution to journalConference articlepeer-review

Abstract

At Rutgers, we have developed a new class of DNA-crosslinked hydrogels that promise to have a wide range of applications ranging from drug delivery to prosthetics. Advantages of using DNA in place of more common crosslinkers such as bis(acrylamide) include thermoreversibility and the ability to engineer the crosslink length. We have shown previously that gel stiffness is a function of the DNA crosslink density, and demonstrated a second method whereby stiffness was enhanced by generating tensegrity within the gel network. In this study, controlled procedures were employed to monitor the extent to which gel compression during electrophoresis influences the stiffness of the gel. The effects of DNA "fuel" and counter-fuel (removal) strands were investigated. A nearly four-fold increase in elastic modulus was reversibly attained by the introduction of fuel strands to stiffen the crosslinks and create a tensegrity microstructure.

Original languageEnglish (US)
Article numberIMECE2004-59615
Pages (from-to)219-220
Number of pages2
JournalAdvances in Bioengineering, BED
DOIs
StatePublished - 2004
Event2004 ASME International Mechanical Engineering Congress and Exposition, IMECE - Anaheim, CA, United States
Duration: Nov 13 2004Nov 19 2004

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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